1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

Name	Hydroxyfasudil
Synonyms	HA1100 HA 1100 HA-1100 Ha 1100 Hydroxyfasudil HYDROXYFASUDIL 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)- 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride
CAS	105628-72-6

Molecular Formula	C14H17N3O3S
Molar Mass	307.37
Storage Condition	Sealed in dry,Store in freezer, under -20°C
In vitro study	Hydroxyfasudil is a ROCK inhibitor, with IC 50 s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC 50 of 37 μM, 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC 50 value of 0.8 ± 0.3 μM. Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μM.
In vivo study	Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats.

Last Update：2024-01-02 23:10:35

biological activity	Hydroxyfasudil is a ROCK inhibitor that can inhibit the activity of ROCK1 and ROCK2 with IC50 values of 0.73 and 0.72 μM respectively.
target	ROCK2 0.72 μ m (IC 50 ) ROCK1 0.73 μ m (IC 50 ) PKA 37 μ m (IC 50 )
in vitro study	Hydroxyfasudil is a ROCK inhibitor, with IC 50 s of 0.73 and 0.72 μ m for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC 50 of 37 μ m, 50-fold higher than that of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC 50 value of 0.8±0.3 μM. Hydroxyfasudil (0-100μM) concentration-dependently increases eNOS activity and stimulates NO production in human aurtic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μ m.
in vivo study	Hydroxyfasudil (10 mg/kg, I. p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, I. p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3,10 mg/kg, I. p) significantly ameliorates decreased penile cGMP contents in rats.

Last Update：2024-04-09 19:05:03

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Product Name: Fasudil Impurity 7 Visit Supplier Webpage Request for quotation
CAS: 105628-72-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: Hydroxyfasudil Visit Supplier Webpage Request for quotation
CAS: 105628-72-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Request for Quotation